For UK and European tech and digital scale-ups, the US market offers unparalleled growth potential. But where should you plant your flag in 2025?

In this informative virtual roundtable, hosted by Mark Stimpfig and Ian Collins of GTM Global, business leaders and economic development experts from six dynamic US regions make a compelling case for looking beyond traditional US tech hubs when expanding into the American market.

The featured regions – Greater Phoenix, Salt Lake City, Northeast Indiana, Tampa Bay, Prince William County (VA), and Charleston – each presented distinct advantages while sharing common themes of lower operating costs, strong talent pipelines, and business-friendly environments.

1. Greater Phoenix: A Hub for Semiconductors, EVs, and Life Sciences

Greater Phoenix emerged as a compelling option for companies in semiconductors, electric vehicles, and life sciences. The region benefits from Arizona State University’s massive talent pipeline and programs specifically designed for international companies, including a soft-landing program. The region’s strategic location between California and Texas provides access to major markets while maintaining lower operating costs, making it an attractive destination for US corporate expansion. Find out more in this regional spotlight.

2. Salt Lake City: A Leader in Business and AI Innovation

Greater Phoenix emerged as a compelling option for companies in semiconductors, electric vehicles, and life sciences. The region benefits from Arizona State University’s massive talent pipeline and programs specifically designed for international companies, including a soft-landing program. The region’s strategic location between California and Texas provides access to major markets while maintaining lower operating costs, making it an attractive destination for US corporate expansion. Find out more in this regional spotlight.

3. Northeast Indiana: A Global Orthopedics Powerhouse

Northeast Indiana highlighted its strength in medical devices and orthopedics, with over 50% of global orthopedic implants manufactured in the region. The area is developing new initiatives in medical technologies, creative industries, and vehicle technologies, supported by major universities like Purdue and Notre Dame. This makes it an ideal alternative business location for international business growth in the US market strategy.

4. Tampa Bay: A Business-Friendly and Tax-Free Destination

Tampa Bay emphasized its business-friendly environment, absence of state income tax, and growing tech and financial services sectors. The region’s quality of life and climate have attracted major corporate relocations, while maintaining strong support for smaller companies entering the US market, making it a prime destination for foreign business in USA. Learn more about this region in this article.

5. Prince William County, Virginia: Proximity to Federal Opportunities

Prince William County, Virginia, leveraged its proximity to Washington DC and federal agencies as a key advantage, particularly for life sciences and technology companies. The region’s collaboration between George Mason University and the private sector has created a thriving ecosystem for biotech innovation, presenting opportunities for US market entry and American business development.

6. Charleston, South Carolina: Ports, Industry, and Life Sciences Growth

Charleston, South Carolina, positioned itself as a rapidly growing region with strong port infrastructure and diverse industry presence, including Boeing, Volvo, and Mercedes manufacturing facilities. The region’s commitment to life sciences is demonstrated by initiatives like the new Blue Sky Labs offering free laboratory space to qualifying companies, making it an attractive option for US business expansion.

Key Considerations for Successful US Expansion

The event emphasized that successful US market entry requires careful consideration of factors beyond just location. Companies need to adequately budget for expansion, with many participants indicating plans to invest over $1 million in their US growth. The importance of managing foreign exchange risk and accessing appropriate funding was highlighted by Raccoon Capital, offering specialized services for international companies.

The Role of Supportive Ecosystems

A common thread across all regions was the high level of support available through economic development organizations, universities, and local business networks. These US business ecosystems offer international companies not just a location, but a community of resources and partners to support their growth.

Conclusion: Match Your Needs with the Right Region

For UK and European companies considering US expansion, these regions present compelling alternatives to traditional coastal hubs, offering lower costs, strong talent pools, and supportive business environments. The key to success appears to lie in matching a company’s specific needs with the right regional ecosystem rather than defaulting to well-known tech hubs. Check out this case study of successful expansion into the US.